After a decade of painstaking research, federal and university scientists have reconstructed the 1918 influenza virus that killed 50 million people worldwide. Like the flu viruses now raising alarm bells in Asia, the 1918 virus was a bird flu that jumped directly to humans, the scientists reported. To shed light on how the virus evolved, the United States Department of Health and Human Services published the full genome of the 1918 influenza virus on the Internet in the GenBank database.

This is extremely foolish. The genome is essentially the design of a weapon of mass destruction. No responsible scientist would advocate publishing precise designs for an atomic bomb, and in two ways revealing the sequence for the flu virus is even more dangerous.

The main objectives of the project are (i) to develop versatile, inexpensive, and easy-to-use diagnostic tools for health, environmental and other applications based on the measurement of molecular interactions (ligand-receptor interactions) by integrated micro- and nano-cantilever sensors and (ii) to test the developed diagnostic tools in two specific health care applications, namely (1) the detection of tumour markers in clinical diagnosis and (2) the high-sensitivity detection of proteins, providing a verification of the project's achievements and initiating a generation of innovative products with significant market potential. The proposed project capitalizes on the mechanical properties of micro- and nano-mechanical structures (cantilevers) to measure molecular (ligand-receptor) interactions.

Is "synthetic biology" on the point of making life? Unlike genetic engineering or biotechnology, the new discipline is not about tinkering with biology but about remaking it. Risks and rewards will be greater than anything yet encountered

Two years ago American scientists created life. Or did they? It all depends on what you mean by life. More specifically, it depends on whether you are prepared to regard viruses as living entities. Viruses have genes, and they replicate, mutate and evolve, all of which sounds lifelike enough. And in August 2002, a team at the State University of New York (SUNY) announced that it had made a virus from scratch, by chemistry alone.

What this meant was that, for the first time since life began over 3.5bn years ago, a living organism had been created with genetic material that was not inherited from a progenitor.

To what did the SUNY researchers choose to award the honour of being the first synthetic organism? They selected a virus that scientists have spent decades trying to eradicate, a cause of human disability and death: polio. If you think that sounds unwise, so did some biologists. Craig Venter, former head of the privately-funded US human genome project conducted by Celera Genomics, called the work "irresponsible" and claimed that it could hurt the scientific community.

Repeatedly invoking the threat of terrorism, the Senate on Wednesday unanimously approved a $5.6-billion, 10-year initiative to encourage private industry to develop vaccines and drugs that would protect Americans from biological, chemical or nuclear attacks.

If terrorists have access to anthrax, smallpox, botulism toxin, plague or Ebola virus, said Sen. Judd Gregg (R-N.H.), "there is no question they will use it. And they will use it in a place where people gather to go about their daily lives."

The Senate vote came more than two years after anthrax-filled letters caused five fatalities, changed the way mail was inspected and delivered, and highlighted the nation's vulnerability to bioterrorist attacks.

President Bush, who on Wednesday praised passage of the bill as "another important step in winning the war on terror," proposed Project Bioshield in his 2003 State of the Union address. The House passed a bill, 421-2, last summer, but the legislation stalled in the Senate over the technical concerns of a handful of lawmakers.

Ray Kurzweil has proposed a nanobiotechnology research program to replace the cell nucleus and ribosome machinery with a nanocomputer and nanobot to prevent diseases and aging and another program to create defensive technologies against rogue designer viruses.

Kurzweil presented the ideas in a keynote at the recent "Breakthrough Technologies for the World's Biggest Problems" conference on April 28, sponsored by the Arlington Institute.

Edward Jenner, the English physician who first developed the smallpox vaccine in 1796, believed that vaccination caused a fundamental change in personal constitution and would lead to lifelong immunity to smallpox. Unfortunately, this proved to be incorrect. It is now clear that immunity wanes over time. Exactly how long the vaccine confers protection, however, is difficult to assess.

Get used to SARS, West Nile, Hantavirus, Ebola, Nipah, Hendra, AIDS and other new nasty infectious diseases. Health experts say we're living in a new age of infections.

And we have mostly ourselves to blame.

The nation's top scientists say that environmental, economic, social and scientific changes have helped to trigger an unprecedented explosion of more than 35 new infectious diseases that have burst upon the world in the past 30 years. The U.S. death rate from infectious disease, which dropped in the first part of the 20th century and then stabilized, is now double what it was in 1980.

Center for Civilian Biodefense Strategies urges oversight of scientific information

The same scientific advances in biotechnology, genetics, and medicine that are intended to improve life could also be used to develop biological weapons capable of causing mass destruction, according to researchers from the Johns Hopkins Bloomberg School of Public Health's Center for Civilian Biodefense Strategies. They urge governments and the scientific community to adopt a system of checks and balances to prevent the misappropriation of scientific discoveries and technology. Their analysis is outlined in an article published in the January 2003 edition of the journal Biosecurity and Bioterrorism.

As early as Monday (2002-12-02), President Bush is expected to order smallpox vaccinations for 500,000 U.S. military personnel and 510,000 civilian medical workers as a precaution against a biological attack by Iraqi agents or other terrorists, administration officials say.