The flip side of the steroid scandal in baseball is last week's announcement of the first cloned dog. Ballplayers are punished for using pharmaceutical technologies to improve their physical abilities, while scientists are rewarded for pushing toward a similar goal — in the words of artificial intelligence techno-visionary Ray Kurzweil, "reverse engineering our biology and then reprogramming it."

Biological engineering is not just about curing disease anymore. The incentives and profits are moving toward drugs, gene therapies and other technologies to enhance human performance — memory, creativity, concentration, strength, endurance, longevity. Asking athletes not to partake of these advances is not just hypocritical, it's likely to be increasingly futile.

Recently, the Partnership for a Drug-Free America recently gave its imprimatur to a new buzzword: Generation Rx. Its annual report on what Americans think of controlled substances showed that for the first time, more teenagers are abusing prescription painkillers than are using a variety of common illicit drugs.

What are these prescription drugs being used for? Some of them mimic the effects of street drugs. For instance, the pain reliever Oxycontin, when stripped of its coating, can produce a heroinlike high. The consequences of this kind of abuse are familiar. Antidrug advocates have warned for decades that drugs impair not only users' health but also their work. Drug-induced torpor even earned its own name: amotivational syndrome. Timothy Leary's flameout on the Harvard fast track probably frightened more middle-class parents than the warnings of J. Edgar Hoover.

But there is an aspect of prescription drug abuse mentioned only briefly in the report: ingesting to excel, not rebel. There's now a hypermotivational syndrome, use of prescription drugs not to escape the commanding heights of education and the economy but to attain them.

In the 70s, the idea seemed so far-fetched that it became a TV series, but the field of bionics, the integration of biology and technology, is gaining strength.

NewsCenter 5's Rhonda Mann reported Friday that a new prosthetic knee, developed using MIT research, is among those leading the way.

It was a hot summer day. John Warren, a scuba diving instructor, was filling an air tank when it exploded.

"I was standing within two feet of the tank and caught the majority of the fragments," Warren said.

His right leg was severed above the knee. His left leg was seriously injured. After being fitted with many prostheses, in February, Warren was one of the first to try a Rheo-Knee.

"Within those 60 steps the patient has to vary their speed a little bit, the knee starts learning how they move, how they walk, and at that point figures out how to adjust itself with the person," Warren said.

What makes the Rheo-Knee different is that it's the first to use artificial intelligence -- tiny sensors that analyze the knee 1,000 times per second allowing it to adjust to any step or misstep.

A new class of drug may increase alertness without any of the jitteriness of over-stimulation, suggest the results of a small clinical trial released this week.

A compound dubbed CX717, a member of the new class called ampakines, significantly improved performance on tests of memory, attention, alertness, reaction time and problem solving in healthy men deprived of sleep.

The study was carried out by Julia Boyle at the Sleep Research Centre at the University of Surrey, UK, and her colleagues on behalf of Cortex Pharmaceuticals Inc., based in Irvine, California, US.

Thanks to laser surgery, Tiger Woods now has better-than-perfect vision. Is it fair play?

Nothing destroys a sporting reputation like steroids. In 1998, Mark McGwire was a baseball hero. Wearing a T-shirt bearing the slogan, "If Popeye wants his arms back - he'll have to wait until October", he obliterated the record for the number of home runs in a season. Last month, McGwire was branded a cheat for using a legal, performance-enhancing steroid precursor, androstenedione, when he achieved the feat.

It may seem like a simple case of right and wrong. McGwire used a steroid precursor, albeit one that was legal in baseball, and he has been punished. But the line between right and wrong in sport is being increasingly blurred. It is now possible to enhance performance through surgery and, very soon, gene therapy. Accusations of double standards are in the air.

When McGwire achieved his record, he was also wearing contact lenses. Natural vision is 20/20, but McGwire's lenses improved his vision to 20/10, so he could see, at a distance of 20ft, what a person of normal vision could see at 10ft. Clearly, that could make a difference when you're trying to hit a fast ball. But the hearing, which criticised him for his artificially enhanced muscles, made no mention of his artificially enhanced eyesight.

In this expanded interview transcript, inventor Ray Kurzweil discusses birth, death, and the potential offered by non-biological thinking processes.
By: Lucas Conley

Fast Company: First off, without death, CEOs will never give up their jobs. There won't be any succession plans.

Ray Kurzweil: I don't think we need to kill people off to provide opportunity for new leadership and creativity. The marketplace of ideas and technologies is going to expand -- it has been for years. Look at the computer industry. 60 years ago it was a handful of research projects, and now it's a trillion-dollar industry.

FC: But biotech? Who's to say how quickly it will advance?

Kurzweil: A lot of people say you can't really tell the future, and there are certain things that are hard to predict. What will Google's stock be three years from now? That's hard to predict. But if you ask me what it will cost to sequence a base pair of DNA in 2010 or the cost to move a megabyte of data wirelessly in 2015, those things turn out to be remarkably predictable.

It would be hard to imagine improving on the intelligence of computer engineer Bjoern Stenger, a doctoral candidate at Cambridge University. Yet for several hours, a pill seemed to make him even brainier.

Participating in a research project, Stenger downed a green gelatin cap containing a drug called modafinil. Within an hour, his attention sharpened. So did his memory. He aced a series of mental-agility tests. If his brainpower would normally rate a 10, the drug raised it to 15, he said.

"I was quite focused," said Stenger. "It was also kind of fun."

The age of smart drugs is dawning. Modafinil is just one in an array of brain-boosting medications — some already on pharmacy shelves and others in development — that promise an era of sharper thinking through chemistry.

These drugs may change the way we think. And by doing so, they may change who we are.

Long-haul truckers and Air Force pilots have long popped amphetamines to ward off drowsiness. Generations of college students have swallowed over-the-counter caffeine tablets to get through all-nighters. But such stimulants provide only a temporary edge, and their effect is broad and blunt — they boost the brain by juicing the entire nervous system.

The new mind-enhancing drugs, in contrast, hold the potential for more powerful, more targeted and more lasting improvements in mental acuity. Some of the most promising have reached the stage of testing in human subjects and could become available in the next decade, brain scientists say.

Thirty years from now, the uproar surrounding Barry Bonds' alleged steroid use might seem quaint by comparison to the human enhancement technologies that could be available then.

In the next few decades, futurists say, athletes and soldiers will call on artificial muscles to lift heavier loads and run faster. Bionic eyes will let them see distant targets, while "nanobots" enhance their cognitive abilities and genetic-engineering techniques boost their performance under pressure.

"The use of anabolic steroids, in retrospect, will seem almost prehistoric — as well as stupid," said Jerome C. Glenn, executive director of the American Council for the United Nations University (Washington) and co-author of the book 2004: State of the Future. "In the future, we'll be able to enhance ourselves in other ways that won't be so dangerous."

The goal of the Extension of the Human Senses project is to advance man machine interfaces by directly connecting a person to a computer via the human electrical nervous system. This involves measuring Electromyogram (EMG) and Electroencephalogram (EEG) signals and applying intelligent pattern recongition software to interpret these signals as computer control commands.
To date we have used EMG signals to eliminate the need for mechanical joysticks and keyboards. As an example of this we have flown a Class IV simulation of a transport aircraft to landing with our EMG based "joystick". We have also demonstrated virtual typing on a keypad using EMG. Our current work is focusing on using brain waves (EEG) to control computer software and the necessary algorithms to support this work.

For a glimpse of what post-human athletes may look like beginning in the 2012 or 2016 Olympics, take a look at an obscure breed of cattle called the Belgian Blue.

Belgian Blues are unlike any cows you've ever seen. They have a genetic mutation that means they do not have effective myostatin, a substance that curbs muscle growth. A result is that Belgian Blues are all bulging muscles without a spot of fat, like bovine caricatures of Arnold Schwarzenegger.

In the popular imagination, the technologically altered human being is a cross between RoboCop and the Borg.

The hardware that would make such a mating of humans, silicon chips and assorted weaponry a reality is, unfortunately, still on back order.

Many people, however, have already made a different kind of leap into the posthuman future.

Their jump is biochemical, mediated by proton-pump inhibitors, serotonin boosters and other drugs that have become permanent additives to many human bloodstreams.

Over the past half century, health-conscious, well-insured, educated people in the United States and in other wealthy countries have come to take being medicated for granted.

What new tools to improve human performance will emerge from the convergence of nanotech, biotech, infotech and cognitive science?

This was topic of discussion at the recent NBIC conference in New York, where several hundred scientists, ethicists, government officials and business executives gathered.

Like nanotechnology 10 years ago, speculating about potential NBIC applications is easy. Developing novel tools that solve real world problems remains hard. Always keeping this in mind, Mike Roco, conference co-chair and architect of the National Nanotechnology Initiative, performs the difficult task of distinguishing practical applications from mere conjecture, while cultivating an environment that encourages exploratory discussions. My goal was to explore the political and economic issues that might arise as these converging technologies make possible neurotechnology -- tools that can influence the brain.

The mere thought of hauling a 70-pound pack across miles of rugged terrain or up 50 flights of stairs is enough to evoke a grimace in even the burliest individuals. But breakthrough robotics research at the University of California, Berkeley, could soon bring welcome relief — a self-powered exoskeleton to effectively take the load off people’s backs.

"We set out to create an exoskeleton that combines a human control system with robotic muscle," said Homayoon Kazerooni, professor of mechanical engineering and director of UC Berkeley’s Robotics and Human Engineering Laboratory. "We’ve designed this system to be ergonomic, highly maneuverable and technically robust so the wearer can walk, squat, bend and swing from side to side without noticeable reductions in agility. The human pilot can also step over and under obstructions while carrying equipment and supplies."

The Berkeley Lower Extremity Exoskeleton (BLEEX), as it’s officially called, consists of mechanical metal leg braces that are connected rigidly to the user at the feet, and, in order to prevent abrasion, more compliantly elsewhere. The device includes a power unit and a backpack-like frame used to carry a large load.

Is society ready for NBIC? As nano, bio, info and cognitive technology increasingly converge, proponents of NBIC (the somewhat clunky acronym for this multitech intersection), are calling for the legal, ethical and regulatory implications to be considered from the very beginning.

The architect of the National Nanotechnology Initiative, Mike Roco, co-editor of a soon-to-be updated report on NBIC convergence and human performance, said at a recent conference that "society needs to be prepared for the major changes to come." Convergent technologies such as augmented vision or hearing, pervasive sensor networks and genetic manipulation will challenge the meaning of human nature and privacy, as well as many aspects of trade and international law.

It may not be long before you hear airport security screeners ask, "Do you plan on hijacking this plane?" A U.S. company using technology developed in Israel is pitching a lie detector small enough to fit in the eyeglasses of law enforcement officers, and its inventors say it can tell whether a passenger is a terrorist by analyzing his answer to that simple question in real-time.

The technology, developed by mathematician Amir Lieberman at Nemesysco in Zuran, Israel, for military, insurance claim and law enforcement use, is being repackaged and retargeted for personal and corporate applications by V Entertainment (New York).