In the beginning, there was music. Childhood and young adulthood floated by to a soundtrack of lyrics and rhythms and searing guitar riffs that consumed you, became you, constituted your identity, galvanized your intent, spoke your soul.

But time passes, classrooms fade to cubicles, and a vast landscape of new music turns foreign and unexplored. For Jeff Hersh, 31, the stereo came to double as Proust's madeleine, its purpose to invoke memories rather than create them.

"Finding music was easier when I was younger," says Hersh, a vice president at Smith Barney in New York. "In college I lived in a fraternity house with 70 guys all around me at all times, listening to various kinds of music. But as you get older, you work more, you get isolated."

Then in November, a friend told Hersh about Pandora.com, an inventive "Internet radio" website that generates music streams — "stations" — based on one's favorite artists or songs. He started his own private thread of music that was a combination of Neil Young and Pearl Jam, Hersh says, and in an hour he heard more new music he liked than he had in the last decade, much of it from obscure bands that shared musical traits with Young and Pearl Jam.

After a decade of painstaking research, federal and university scientists have reconstructed the 1918 influenza virus that killed 50 million people worldwide. Like the flu viruses now raising alarm bells in Asia, the 1918 virus was a bird flu that jumped directly to humans, the scientists reported. To shed light on how the virus evolved, the United States Department of Health and Human Services published the full genome of the 1918 influenza virus on the Internet in the GenBank database.

This is extremely foolish. The genome is essentially the design of a weapon of mass destruction. No responsible scientist would advocate publishing precise designs for an atomic bomb, and in two ways revealing the sequence for the flu virus is even more dangerous.

Parents who worry that video games are teaching kids to settle conflicts with blasters and bloodshed can take heart: A new generation of video games wants to save the world through peace and democracy.

A team at Carnegie Mellon University is working on an educational computer game that explores the Mideast conflict -- you win by negotiating peace between Israelis and Palestinians. This spring, the United Nations' World Food Programme released an online game in which players must figure out how to feed thousands of people on a fictitious island.

This weekend, the University of Southern California is kicking off a competition to develop a game that promotes international goodwill toward the United States, a kind of Voice of America for the gamer set.

And lest anyone think only professors and policy wonks are involved, a unit of MTV this week announced a contest to come up with a video game that fights genocide in Darfur, Sudan.

Internet-based computer games, in which players create characters in a virtual world and interact to solve problems or win battles, are branching out from fantasy into serious social issues. Academics recognize their power as a new form of mass entertainment, and activists hope to tap into their enormous worldwide popularity to reach a new generation used to interacting through computers.

At the end of the 19th century, L. L. Zamenhof proposed Esperanto; it was intended as a global language to be spoken and understood by everyone. The inventor was hoping that a common language could resolve global problems that lead to conflict. Esperanto as a planned language might have had some success, but today, English is much more universal. 30 countries have it as an official language, and in many other countries it is taught in school and understood fairly well. The internet can be suspected to further increase the adoption of English.

Still, many people can’t speak English. The collected, shared knowledge that makes up the web is therefore only partly accessible to them. The reverse, of course, is true as well. When you surf the web, you will sometimes come across languages and characters you don’t understand – like Chinese, Arabic, Korean, French, German, Italian, Spanish, or Japanese. Would you be able to fluently read these languages, those sites wouldn’t be a dead end for you. You would discover a wealth of knowledge, and more importantly, opinions. If you’re an US citizen, how many Arabic, German or French sources do you read to get a good understanding of how the world sees the US? How many blogs do you read in foreign languages? Probably not many, unless you’re fluent in those languages.

At the recent web cast of the Google Factory Tour, researcher Franz Och presented the current state of the Google Machine Translation Systems. He compared translations of the current Google translator, and the status quo of the Google Research Lab’s activities. The results were highly impressive. A sentence in Arabic which is now being translated to a nonsensical “Alpine white new presence tape registered for coffee confirms Laden” is now in the Research Labs being translated to “The White House Confirmed the Existence of a New Bin Laden Tape.”

From design to delivery, custom manufacturing is coming soon to a desktop near you. Writer Clive Thompson joins the fab Lab" revolution.

If you could make anything you wanted, what would it be?

For me, that's not a rhetorical question, because right now I'm staring at my own personal fabricator. It's eMachineShop, an application that produces a physical 3-D copy of almost anything I draw. "You know the machine on Star Trek? The replicator? That's what I was aiming for," says Jim Lewis, the guy who created this tool.

The concept is simple: Boot up your computer and design whatever object you can imagine, press a button to send the CAD file to Lewis' headquarters in New Jersey, and two or three weeks later he'll FedEx you the physical object. Lewis launched eMachineShop a year and a half ago, and customers are using his service to create engine-block parts for hot rods, gears for home-brew robots, telescope mounts - even special soles for tap dance shoes. "Designing stuff used to be just for experts," Lewis says. "We're bringing it to the masses."

Nicholas Negroponte, chairman and founder of the Massachusetts Institute of Technology Media Labs, has been outlining designs for a sub-$100 PC.

The laptop will be tough and foldable in different ways, with a hand crank for when there is no power supply.

Professor Negroponte came up with the idea for a cheap computer for all after visiting a Cambodian village.

His non-profit One Laptop Per Child group plans to have up to 15 million machines in production within a year.

A prototype of the machine should be ready in November at the World Summit on the Information Society (WSIS) in Tunisia.

Children in Brazil, China, Egypt, Thailand, and South Africa will be among the first to get the under-$100 (£57) computer, said Professor Negroponte at the Emerging Technologies conference at MIT.

The following year, Massachusetts governor Mitt Romney plans to start buying them for all 500,000 middle and high school pupils in the state.

Professor Negroponte predicts there could be 100 million to 150 million shipped every year by 2007.

Of all the cool, futuristic machines featured on the television series Star Trek, the "replicator" was certainly one of the most useful.

A character simply asked for a cup of tea, and voila - the replicator would make a cuppa.

A machine that can make anything sounds like the stuff of the distant future, but a Massachusetts Institute of Technology (MIT) program is making personal fabrication a reality.

Around the world, MIT is helping to build Fabrication, or "Fab" Labs, and they are reaping results.

Researchers have developed a new hand-held device that can produce room-temperature plasmas for biomedical applications. The source, which was developed by Mounir Laroussi and XinPei Lu at the Old Dominion University in Virginia, could be used to kill bacteria, heal wounds and treat plaque (Appl. Phys. Lett. 87 113902).

Air-raid sirens, Frank Sinatra songs and Muhammad Ali trash talk blared over the Southern California desert in a demonstration of new acoustic technology for crowd control and disaster communications.

In mid-90's morning heat at Edwards Air Force Base, HPV Technologies and American Technology demonstrated prototypes of non-lethal sonic devices for a group of military and law enforcement guests, including representatives of the U.K. Home Office.

Representatives of both companies say that within days, they will ship some units of their respective products to areas hit by Hurricane Katrina, so authorities can use the tools for crowd control, aid distribution and rescue operations.

A global race is under way to reach the next milestone in supercomputer performance, many times the speed of today's most powerful machines.

And beyond the customary rivalry in the field between the United States and Japan, there is a new entrant - China - eager to showcase its arrival as an economic powerhouse.

The new supercomputers will not be in use until the end of the decade at the earliest, but they are increasingly being viewed as crucial investments for progress in science, advanced technologies and national security.

Once the exclusive territory of nuclear weapons designers and code breakers, ultrafast computers are increasingly being used in everyday product design. Procter & Gamble used a supercomputer to study the airflow over its Pringles potato chips to help stop them from fluttering off the company's assembly lines.

IBM plans to give away key search technologies for corporate data retrieval that use concepts and facts instead of simpler "keyword" searches relied upon by consumer Web companies such as Google Inc., the world's largest computer company said on Monday.

While simple but powerful keyword searches have revolutionized how Internet users locate and retrieve information, IBM is looking to transform how office workers sift through the piles of data stored inside organizations.

"I don't see any of the major players moving into this area," Arthur Ciccolo, head of search technology at IBM Research, said of how major consumer Internet search companies such as Google, Yahoo Inc. and Microsoft have focused on the public Internet instead of private record data retrieval.

IBM plans to openly offer other software developers its Unstructured Information Management Architecture (UIMA), a technology that can analyze text within documents and other media to understand latent meanings, relationships and facts.

Already being intensely studied as an agent for cleaning up toxic waste, a strain of bacteria has now surprised researchers with its ability to build conducting nanowires.

The long, very thin wires are unprecedented in biological systems, says the microbiologist who discovered the bacteria and the wires' conductivity. They completely change science's understanding of how microbes handle electrons, he said.

Derek Lovley and his colleagues at the University of Massachusetts (Amherst, Mass.) reported observing and measuring the conductivity of long wires, 3 to 5 nanometers in diameter, emanating from the Geobacter bacteria.

The Netscape IPO wasn't really about dot-commerce. At its heart was a new cultural force based on mass collaboration. Blogs, Wikipedia, open source, peer-to-peer - behold the power of the people.

Ten years ago, Netscape's explosive IPO ignited huge piles of money. The brilliant flash revealed what had been invisible only a moment before: the World Wide Web. As Eric Schmidt (then at Sun, now at Google) noted, the day before the IPO, nothing about the Web; the day after, everything.

Computing pioneer Vannevar Bush outlined the Web's core idea - hyperlinked pages - in 1945, but the first person to try to build out the concept was a freethinker named Ted Nelson who envisioned his own scheme in 1965. However, he had little success connecting digital bits on a useful scale, and his efforts were known only to an isolated group of disciples. Few of the hackers writing code for the emerging Web in the 1990s knew about Nelson or his hyperlinked dream machine.

At the suggestion of a computer-savvy friend, I got in touch with Nelson in 1984, a decade before Netscape. We met in a dark dockside bar in Sausalito, California. He was renting a houseboat nearby and had the air of someone with time on his hands. Folded notes erupted from his pockets, and long strips of paper slipped from overstuffed notebooks. Wearing a ballpoint pen on a string around his neck, he told me - way too earnestly for a bar at 4 o'clock in the afternoon - about his scheme for organizing all the knowledge of humanity. Salvation lay in cutting up 3 x 5 cards, of which he had plenty.

Although Nelson was polite, charming, and smooth, I was too slow for his fast talk. But I got an aha! from his marvelous notion of hypertext. He was certain that every document in the world should be a footnote to some other document, and computers could make the links between them visible and permanent. But that was just the beginning! Scribbling on index cards, he sketched out complicated notions of transferring authorship back to creators and tracking payments as readers hopped along networks of documents, what he called the docuverse. He spoke of "transclusion" and "intertwingularity" as he described the grand utopian benefits of his embedded structure. It was going to save the world from stupidity.

I believed him. Despite his quirks, it was clear to me that a hyperlinked world was inevitable - someday. But looking back now, after 10 years of living online, what surprises me about the genesis of the Web is how much was missing from Vannevar Bush's vision, Nelson's docuverse, and my own expectations. We all missed the big story. The revolution launched by Netscape's IPO was only marginally about hypertext and human knowledge. At its heart was a new kind of participation that has since developed into an emerging culture based on sharing. And the ways of participating unleashed by hyperlinks are creating a new type of thinking - part human and part machine - found nowhere else on the planet or in history.

Not only did we fail to imagine what the Web would become, we still don't see it today! We are blind to the miracle it has blossomed into. And as a result of ignoring what the Web really is, we are likely to miss what it will grow into over the next 10 years. Any hope of discerning the state of the Web in 2015 requires that we own up to how wrong we were 10 years ago.

Recently, the Partnership for a Drug-Free America recently gave its imprimatur to a new buzzword: Generation Rx. Its annual report on what Americans think of controlled substances showed that for the first time, more teenagers are abusing prescription painkillers than are using a variety of common illicit drugs.

What are these prescription drugs being used for? Some of them mimic the effects of street drugs. For instance, the pain reliever Oxycontin, when stripped of its coating, can produce a heroinlike high. The consequences of this kind of abuse are familiar. Antidrug advocates have warned for decades that drugs impair not only users' health but also their work. Drug-induced torpor even earned its own name: amotivational syndrome. Timothy Leary's flameout on the Harvard fast track probably frightened more middle-class parents than the warnings of J. Edgar Hoover.

But there is an aspect of prescription drug abuse mentioned only briefly in the report: ingesting to excel, not rebel. There's now a hypermotivational syndrome, use of prescription drugs not to escape the commanding heights of education and the economy but to attain them.